Labex GRAL, Grenoble Alliance for Integrated Structural & Cell Biology

The GRAL “Laboratory of excellence” (Grenoble Alliance for Integrated Structural Cell Biology) is constituted by two institutes (BIG – IBS). The GRAL’S priority is deciphering and integrating knowledge on the structure and dynamics of proteins and their function in the cellular context, both in space and time. This approach will allow the understanding of the modulation of the biological functions, and will open the way to major advances in health, environment and biotechnologies.


  • Recombinant expression of the precursor of the hemorrhagic metalloproteinase HF3 and its non-catalytic domains using a cell-free synthesis system.

    Menezes MC, Imbert L, Kitano ES, Vernet T, Serrano SM. – Amino Acids. 2016 Sep;48(9):2205-14

    Structural insights into the Escherichia coli lysine decarboxylases and molecular determinants of interaction with the AAA+ ATPase RavA.

    Kandiah E, Carriel D, Perard J, Malet H, Bacia M, Liu K, Chan SW, Houry WA, Ollagnier de Choudens S, Elsen S, Gutsche I.
    Sci Rep
    . 2016 Apr 15;6:24601. doi: 10.1038/srep2460


  • All publications
  • Events

    1. Labex GRAL Evaluation 2015

      August 24, 2015 @ 8:00 am - December 31, 2019 @ 5:00 pm
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