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Starting Grant in Biology

The Unviversité Grenoble Alpes recruits an excellent young researcher to set up a new group either at the “Institut de Biologie Structurale” (IBS), or at the “Biosciences and Biotechnology Institute of Grenoble” (BIG) –To know more about the application form

 BIG – Junior team leader positions

BIG is currently seeking junior group leaders to set up research teams with starting grants such as ATIP-Avenir and/or ERC. Successful candidates will be supported by BIG to obtain permanent positions at one of the major French research organizations. The research programs carried out should be relevant to the BIG scientific project, with the aim to seek collaborations inside the institute and within the Grenoble scientific environment. Applicants are expected to propose an independent research project within the 3 profiles described below. Candidates with excellent track records are invited to submit a single file including their CV, the complete list of publications, a summary of scientific achievements, proposed research (maximum 3 pages), and contact details for three referees to Jérôme GARIN, ideally before September 15th 2017.

– Young investigator with a strong expertise in medicinal chemistry

To develop new concepts in drug delivery for cancer therapy and infectious disease treatment. The candidate should perform an independent research program extending from the design and synthesis of novel molecules to in vivo assays. The applicant will benefit from the strong expertise present at BIG in the fields of synthetic chemistry and cell biology and have access to different platforms (high throughput screening, RMN, Mössbauer) and state of the art instrumentation (X-ray crystallography, imaging techniques).

– Young investigator expert in bioinspired multicellular 3D architectures

Such as human organoids. The candidate will benefit from state-of-the-art environment in microfabrication, microfluidic, 3D culture of human cells, live cell imaging technologies, RNAi-based high content and high throughput screening, proteomics, to develop her/his own project research using human organoids to decipher basic principles that govern organ development, function and disease. On a longer term this project could also help the discovery of new biomarkers and therapeutic targets in diseases, particularly in oncology. Eventually, these models will optimize drug development while reducing the use of animal models. The candidate should have an excellent experience in cell biology, particularly stem cell, 3D cultures of mammalian cells, but also in micro technologies, microfluidic and microfabrication.

– Young investigator with a strong interest in studying the molecular and architectural organization of photosynthetic membranes in unicellular phototrophs, and their dynamic responses to environmental stresses (e.g. nutrient starvation, light, oxidative stress and heavy metals pollution). Using structural cell biology and single-cell physiology, she/he will reassess structural features of chloroplasts, offering new ideas on how to optimize their photosynthesis, and illustrate possible molecular responses to future ocean environments. Thus, her/his work will be relevant to climate changes, environment and possible biotechnology applications of photosynthetic organisms. The applicant should have excellent record in microscopy/single cell physiology, including cryo preparation, tomography, investigation of physiology/metabolism.

Candidates with excellent track records are invited to submit a single file including their CV, the complete list of publications, a summary of scientific achievements, proposed research (maximum 3 pages), and contact details for three referees to Jérôme GARIN, ideally before September 15th 2017.

  IBS-Junior team leader positions 

The “Institut de Biologie Structurale” of Grenoble is currently seeking junior group leaders to set up research teams in the field of integrated structural cell biology with starting grants such as ATIP-Avenir and/or ERC. Successful candidates will be supported by the IBS to obtain permanent positions at one of the major French research organizations.
The IBS is located on the European Photon and Neutron campus, next to its international partners EMBL, ILL and ESRF forming one of the largest European Centers in Structural Biology organized within the PSB (Partnership for Structural Biology). The IBS performs interdisciplinary research in integrated structural biology along 3 main axes: Infection and Molecular Medicine, Membrane Signaling and Transport, Frontiers in Biophysics and Chemistry for Structural Biology. Research at IBS benefits from access to state of the art equipment at IBS including high-field NMR (5 spectrometers including a 950 MHz), and electron microscopy for single particle analysis and electron tomography (3 microscopes including a Polara 300 kV equipped with a K2 detector), spinning disk and super-resolution fluorescence microscopy, and an ensemble of instruments to produce and characterize biological samples at the molecular level. This is complemented by access to ILL neutron sources and ESRF beam lines including the Titan Krios electron microscopy platform that will be operated jointly by ESRF, EMBL and IBS starting in 2017.
Applicants are expected to propose an independent research project within the 3 profiles described below.
Candidates with excellent track records are invited to submit a single file including their CV, the complete list of publications, a summary of scientific achievements, proposed research (maximum 3 pages), and contact details for three referees to Winfried Weissenhorn ideally before Jun 20th 2017. However, applications will be considered until the position(s) have been filled.

-Young investigator in structural biology and biophysics of membrane proteins

The IBS aims to strengthen its activity in structural biology of membrane proteins. Several IBS teams have built-up strong expertise in biochemistry, biophysics and crystallization of membrane proteins, including in the development of novel approaches to study the molecular mechanisms of receptors, ion channels and transporter. The candidate will benefit from the existing expertise and access to crystallization platforms (hanging drops and in meso) equipped with state of the art instruments to analyze membrane proteins. The successful candidate should have experience in X-ray crystallography and/or single particle electron microscopy of membrane proteins and should propose a project relevant to one of the three main research axes of the IBS with a strong focus on structure-function analyses.

-Young investigator in computational methods for structural biology

The IBS seeks to recruit an expert in computational methods, its development and application to respond to important biological questions. The candidate should propose her or his own research project relevant to the main research axes performed at IBS and should be open for collaborative projects with IBS groups. The ideal candidate should investigate structure, function and dynamics of biological systems or should have a strong expertise in modelling complex biological systems. A solid knowledge of state of the art structural biology data acquisition (X-ray and/or, neutrons and/or XFEL or NMR, or microscopy) will be considered a plus.

-Young investigator for integrated structural cell biology

The IBS seeks to recruit a young investigator with a strong program in structural cell biology addressing important general and/or pathogenic cellular processes. The applicant is expected to have excellent expertise in microscopy including super-resolution fluorescence microscopy and experience or a strong interest to establish correlative electron microscopy. The IBS provides access to inhouse state of the art microscopy equipment including super-resolution fluorescence microscopy and equipment to perform cellular tomography by high pressure freezing techniques and/or CEMOVIS. The candidate should develop an independent research program relevant to the IBS main axes and collaborations with IBS groups are highly encouraged.

 ABOUT GRENOBLE

Capital of the French Alps, Grenoble is exceptionally well situated at the foot of three mountain ranges and offers many possibilities for cultural, outdoor and sporting activities throughout the year. International and national airports are close by, and Paris is only three hours away by the TGV rail link.

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